My research focus is on how bacteria utilize signaling nucleotides known as alarmones to regulate its physiology, in particular survival against antibiotics. Outside of the lab I like running, cooking, watching movies and origami.
Publications
- Fung DK, Trinquier AE, Wang JD (2023) Crosstalk between (p)ppGpp and other nucleotide second messengers. Curr. Opin. Microbiol. 76:102398 PMC10842992 · Pubmed · DOI
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- Yang J, Barra JT, Fung DK, Wang JD (2022) Bacillus subtilis produces (p)ppGpp in response to bacteriostatic antibiotic chloramphenicol to prevent its potential bactericidal effect. mLife. 1(2):101-113 · DOI
- Anderson BW, Fung DK, Wang JD (2021) Regulatory Themes and Variations by the Stress-Signaling Nucleotide Alarmones (p)ppGpp in Bacteria. Annu. Rev. Genet. 55:115-133 · Pubmed · DOI
- Fung DK, Yang J, Stevenson DM, Amador-Noguez D, Wang JD (2020) Small Alarmone Synthetase SasA Expression Leads to Concomitant Accumulation of pGpp, ppApp, and AppppA in Bacillus subtilis. Front. Microbiol. 11:2083 PMC7492591 · Pubmed · DOI
- Fung DK, Barra JT, Schroeder JW, Ying D, Wang JD (2020) A shared alarmone-GTP switch underlies triggered and spontaneous persistence. bioRxiv. · DOI
- Sun J, Deng Z, Fung DK, Yan A (2018) Study of the Expression of Bacterial Multidrug Efflux Pumps in Anaerobic Conditions. In: Yamaguchi A, Nishino K (eds) Bacterial Multidrug Exporters. Methods Mol Biol. 1700:253-268 · Pubmed · DOI
- Fung DK, Anderson BW, Tse JL, Wang JD (2017) 15. Nucleotide Second Messengers: (p)ppGpp and Cyclic Dinucleotides. In: Graumann PL (ed) Bacillus: Cellular and Molecular Biology (Third Edition). Caister Academic Press. 439-466 · DOI
- Fung DK, Ma Y, Xia T, Luk JCH, Yan A (2016) Signaling by the heavy-metal sensor CusS involves rearranged helical interactions in specific transmembrane regions. Mol Microbiol. 100(5):774-87 · Pubmed · DOI
- Fung DK, Lau WY, Chan WT, Yan A (2013) Copper efflux is induced during anaerobic amino acid limitation in Escherichia coli to protect iron-sulfur cluster enzymes and biogenesis. J Bacteriol. 195(20):4556-68 PMC3807430 · Pubmed · DOI
- Fung DK, Chan EWC, Chin ML, Chan RCY (2010) Delineation of a bacterial starvation stress response network which can mediate antibiotic tolerance development. Antimicrob Agents Chemother. 54(3):1082-93 PMC2825962 · Pubmed · DOI
- Chow VCY, Hawkey PM, Chan EWC, Chin ML, Au TK, Fung DKC, Chan RCY (2007) High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianus. Antimicrob Agents Chemother. 51(7):2508-13 PMC1913282 · Pubmed · DOI