Danny Fung

Position title: Asst Scientist

Email: kfung6@wisc.edu

Phone: (608) 263-1072

Danny Fung

My research focus is on how bacteria utilize signaling nucleotides known as alarmones to regulate its physiology, in particular survival against antibiotics. Outside of the lab I like running, cooking, watching movies and origami.


  • Fung DK, Wang JD (2023) The τ of alarmone hydrolysis. Nat Chem Biol. 19(3):257-258 · Pubmed · DOI
  • Fung DK, Bai K, Yang J, Xu X, Stevenson DM, Amador-Noguez D, Luo L, Wang JD (2022) Metabolic Promiscuity of an Orphan Small Alarmone Hydrolase Facilitates Bacterial Environmental Adaptation. mBio. 13(6):e0242222 PMC9765508 · Pubmed ·  DOI
  • Yang J, Barra JT, Fung DK, Wang JD (2022) Bacillus subtilis produces (p)ppGpp in response to bacteriostatic antibiotic chloramphenicol to prevent its potential bactericidal effect. mLife. 1(2):101-113 · DOI
  • Anderson BW, Fung DK, Wang JD (2021) Regulatory Themes and Variations by the Stress-Signaling Nucleotide Alarmones (p)ppGpp in Bacteria. Annu. Rev. Genet. 55:115-133 · Pubmed · DOI
  • Fung DK, Yang J, Stevenson DM, Amador-Noguez D, Wang JD (2020) Small Alarmone Synthetase SasA Expression Leads to Concomitant Accumulation of pGpp, ppApp, and AppppA in Bacillus subtilisFront. Microbiol. 11:2083 PMC7492591 · Pubmed · DOI
  • Fung DK, Barra JT, Schroeder JW, Ying D, Wang JD (2020) A shared alarmone-GTP switch underlies triggered and spontaneous persistence. bioRxiv. · DOI
  • Sun J, Deng Z, Fung DK, Yan A (2018) Study of the Expression of Bacterial Multidrug Efflux Pumps in Anaerobic Conditions. In: Yamaguchi A, Nishino K (eds) Bacterial Multidrug Exporters. Methods Mol Biol. 1700:253-268 · Pubmed · DOI
  • Fung DK, Anderson BW, Tse JL, Wang JD (2017) 15. Nucleotide Second Messengers: (p)ppGpp and Cyclic Dinucleotides. In: Graumann PL (ed) Bacillus: Cellular and Molecular Biology (Third Edition). Caister Academic Press. 439-466 · DOI
  • Fung DK, Ma Y, Xia T, Luk JCH, Yan A (2016) Signaling by the heavy-metal sensor CusS involves rearranged helical interactions in specific transmembrane regions. Mol Microbiol. 100(5):774-87 · Pubmed · DOI
  • Fung DK, Lau WY, Chan WT, Yan A (2013) Copper efflux is induced during anaerobic amino acid limitation in Escherichia coli to protect iron-sulfur cluster enzymes and biogenesis. J Bacteriol. 195(20):4556-68 PMC3807430 · Pubmed · DOI
  • Fung DK, Chan EWC, Chin ML, Chan RCY (2010) Delineation of a bacterial starvation stress response network which can mediate antibiotic tolerance development. Antimicrob Agents Chemother. 54(3):1082-93 PMC2825962 · Pubmed · DOI
  • Chow VCY, Hawkey PM, Chan EWC, Chin ML, Au TK, Fung DKC, Chan RCY (2007) High-level gentamicin resistance mediated by a Tn4001-like transposon in seven nonclonal hospital isolates of Streptococcus pasteurianusAntimicrob Agents Chemother. 51(7):2508-13 PMC1913282 · Pubmed · DOI